![]() ![]() Patients (and caregivers of patients) should be advised to seek medical advice should signs of suicidal ideation or behaviour emerge. Therefore patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered. ![]() The mechanism of this risk is not known and the available data do not exclude the possibility of an increased risk for Clonex (Clonazepam). A meta-analysis of randomised placebo controlled trials of anti-epileptic drugs has also shown a small increased risk of suicidal ideation and behaviour. Suicidal ideation and behaviour have been reported in patients treated with anti-epileptic agents in several indications. Before adding Clonex (Clonazepam) to an existing anticonvulsant regimen, it should be considered that the use of multiple anticonvulsants may result in an increase of undesired effects. If status epilepticus occurs in a patient receiving oral Clonex (Clonazepam), administration of an intravenous Clonex (Clonazepam) injection may still control the status. The dosage of each drug may be required to be adjusted to obtain the optimum effect. Simultaneous administration of more than one antiepileptic drug is a common practice in the treatment of epilepsy and may be undertaken with Clonex (Clonazepam). Once the maintenance dose level has been reached, the daily amount may be given in a single dose in the evening. If doses are not equally divided, the largest dose should be given before retiring. The daily dose should be divided into 4 equal doses. The maintenance dosage must be determined according to clinical response and tolerance. The dosage of Clonex (Clonazepam) must be adjusted to the needs of each individual and depends on the individual response to therapy. The dose may be increased progressively until the maintenance dose suited to the individual patient has been found. Treatment should be started with low doses. It should be noted that for oral syringes, the product may cause the plunger to stop moving smoothly or the markings may fade over time. The product is incompatible with polystyrene or PVC and therefore, other devices may react with the product. When these instructions are followed over 95% of the dose is delivered. Suitable for administration via non-PVC nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG) tubes. The maintenance dose should be attained after 2 to 4 weeks of treatment.ĭue to the presence of ethanol in the formulation, this product is not indicated for paediatric use.Ī 2.5ml/ 5ml double ended spoon with a further 1.25ml graduation is supplied with the pack. If necessary, larger doses may be given at the discretion of the physician, up to a maximum of 20mg daily. ![]() These are total daily dosages which should be divided into 4 doses taken at intervals throughout the day. It is recommended that the initial dosage of Clonex (Clonazepam) should not exceed 0.5mg/day. The elderly are particularly sensitive to the effects of centrally depressant drugs and may experience confusion. The maintenance dosage for adults normally falls within the range 4 to 8mg. Initial dosage should not exceed 1mg/day. The 2mg/5ml oral solution should be used for maintenance and maximum dosage regimens. The 0.5mg/5ml oral solution may facilitate the administration of lower daily doses in the initial stages of treatment or treatment for the elderly. ![]()
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